Methods: In total, 171 subjects with T2DM were using CSII and divided into different groups according to their body mass index (BMI) and the course of disease, respectively. The basal rate of CSII was set for four periods per day. We preferentially adjusted the basal insulin dose to control fasting and preprandial blood glucose. 

 

       Results: Good glycemic control was achieved after 4.8±2.5 days. The mean total daily insulin dose was 31.66±9.85?IU, and the dose per unit body weight was 0.48±0.19?IU/kg/day. The total daily basal and bolus doses were 21.14±7.64?IU and 10.38±3.62?IU, respectively (i.e., about 66.7±6.8% and 33.3±6.8% of the total daily dose). We did not observe any significant difference in total dose of insulin or basal and bolus doses of insulin per day among different groups divided by BMI. Only in the group with BMI of <23?kg/m(2) was the insulin dose of per kilogram of body weight (0.60±0.25?IU/kg/day) significantly higher than in the other two groups (P=0.0001). There was no relationship between the insulin dose and the course of disease. Conclusions: In individuals with T2DM on CSII short-term intensive therapy, proper increase of basal dose of insulin and preferential adjustment of the basal rate may be the effective method that can achieve good glycemic control with a lower total daily dose.

 

     高冠起等对171例受试者进行研究后发现，在接受连续皮下胰岛素注射（CSII）短期强化降糖治疗的2型糖尿病患者中，适当增加基础胰岛素剂量和调整基础输注速度可提高血糖控制率，还能减少每日胰岛素总用量。

 

       研究者入选171例应用CSII的2型糖尿病患者，根据其体质指数（BMI）和病程分组。研究者通过优先调整基础胰岛素剂量来控制空腹血糖和餐前血糖。结果显示，平均治疗4.8 d时，受试者的血糖控制良好。每日平均胰岛素总用量为31.66 IU，每日每公斤体重的胰岛素用量为0.48 IU；每日基础和餐前胰岛素总剂量分别为21.14 IU和10.38 IU。除BMI<23 kg/m2组中每日每公斤体重胰岛素用量（0.60 IU）较高外，不同BMI组中每日胰岛素总剂量、基础或餐前胰岛素用量均无显著差异。