会议预告

产品新闻

甘精胰岛素不同使用时间比较

A Randomized Clinical Trial Comparing Breakfast, Dinner, or Bedtime Administration of Insulin Glargine in Patients With Type 1 Diabetes

OBJECTIVE— Insulin glargine (Lantus), a long-acting human insulin analog, provides effective glycemic control when administered at bedtime. This open-label, randomized, parallel
group, multicenter study investigated whether insulin glargine is equally effective if administered before breakfast, before dinner, or at bedtime.

RESEARCH DESIGN AND METHODS— Patients with type 1 diabetes on basal-bolus therapy (n  378, 18–68 years, HbA1c 5.5–9.8%) were treated with once-daily individually titrated insulin glargine in combination with prandial insulin lispro for 24 weeks.

RESULTS— Baseline characteristics were similar in the three groups (overall age 40.911.9 years, diabetes duration 17.3  11.5 years). Median total daily insulin dose was similar at
baseline (0.65, 0.65, and 0.66 IU/kg for breakfast, dinner, and bedtime, respectively) and remained relatively constant over the study period; however, the insulin glargine–to–total insulin dose ratio increased more in the breakfast group than in the dinner and bedtime groups. A similar reduction of adjusted mean HbA1c from baseline to end point occurred in all patients
(7.6 –7.4, 7.6 –7.5, and 7.6–7.5% for breakfast, dinner, and bedtime, respectively), and a similar percentage achieved HbA1c 7.0% at end point in all groups (29.5, 29.8, and 25.8%, respectively).

The 24-h blood glucose profiles in relation to injection time were similar in all groups. The incidences of total symptomatic and severe hypoglycemia did not differ between the three
treatment groups; however, nocturnal hypoglycemia occurred in significantly fewer patients in the breakfast group (59.5%) compared with the dinner (71.9%) and bedtime (77.5%) groups
(P  0.005).

CONCLUSIONS— These data suggest that insulin glargine, in combination with insulin lispro, is safe and effective when administered before breakfast, before dinner, or at bedtime.

 

全文检索小助手:

如果您有“基础胰岛素相关文献全文”的检索需求,敬请联系help.basalinsulin@gmail.com,我们将为您搜索并发送到您的邮箱内! 请在“全文求助”邮件内尽量详细说明“标题、作者、杂志及卷期、PMID、全文链接”等内容,以便我们更精准地进行搜索!

求助全文

最新评论 暂无评论

不能超过250字,需审核,请自觉遵守互联网相关政策法规