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2型糖尿病以及糖尿病前期和代谢综合征

Series Editor’s Introduction

 

    Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide toDiagnosis and Management is an important addition to the literature for primary care physicians.It covers concisely and with attention to clinical relevance the full spectrum of insulinresistance and diabetes. This book gives a practical, no-nonsense approach to understandingthe basic pathophysiology of diabetes and the metabolic syndrome, an approach to treatmentwith oral agents and insulin, and an approach to risk factor management. By putting all thisinformation in one readable text, Dr. Codario provides a service to us all, facilitating theunderstanding of a body of knowledge that cannot be obtained through any attempt to readportions of much larger textbooks in the field.
 
    This textbook will serve as a resource for medical students, residents in family medicineand internal medicine, and attending physicians who wish to update and improve their knowledgein the field of diabetes and the newly emerging science of the metabolic syndrome. Inaddition, it allows attending physicians the opportunity to obtain Continuing Medical Educationcredits while performing self-directed learning. At the end of reading Type 2 Diabetes,Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis andManagement, the physician should feel comfortable and confident that they have acquired asolid understanding of the latest information in the field, and by so doing, should be betterable to take excellent care of patients with diabetes and the metabolic syndrome.
 
Neil S. Skolnik, MD
Abington Memorial Hospital
Abington, PA
and
Temple University School of Medicine
Philadelphia, PA
 
Preface
 
    Diabetes has become an increasing problem throughout the world, with an estimated 300million people expected to be diagnosed with the disease in the next 10 years. One hundredand fifty million people worldwide and 18.2 million people in the United States are currentlyafflicted, an additional 5.2 million are undiagnosed, and close to 16 million are insulinresistant.More than 9 million women, 8 million men, and 120,000 children under 18 yearsof age currently have this disease .
 
    Increasing obesity, dietary indiscretions, progressive physical inactivity, and advancingage of the population have all contributed to a sharp rise in the disease. In 1992, 2–4% of allnewly diagnosed cases of diabetes in children were type 2 diabetes. By 1999, this numberhad risen to 45%. African Americans are more hyperinsulinemic and insulin-resistant atpuberty with lower resting metabolic rates than white children.
 
    According to statistics published by The American Diabetic Association, 15% of the USpopulation has either impaired fasting glucose (6.9%), confirmed diabetes (5.9%), or undiagnoseddiabetes (2.8%), including an alarming 22.7% of Mexican-Americans (9.3% confirmed,4.5% undiagnosed, and 8.9% impaired fasting glucose), and 18.8% ofAfrican-American non-Hispanics (8.2% confirmed, 3.6% undiagnosed, and 7% impairedfasting glucose).
 
    Since 1980, the incidence rate of type 2 diabetes has increased by nearly 20%, with afivefold increase in children and adolescents since 1994. Each year, more than 798,000 newcases are diagnosed in the United States alone, with close to 180,000 diabetics succumbingto the disease and its devastations. Since 1970, the occurrence rate of this disease has risen700% in this country alone. According to the Centers for Disease Control and Prevention,33% of men and 39% of women born in 2000 will develop diabetes. The highest lifetimerisks are 45% for Hispanic men and 53% for Hispanic women. By the year 2025, nearly 22million adults in the United States and 300 million adults worldwide will have diabetes! Thisdisease is the leading cause of end-stage kidney disease and blindness in individualsbetween 20 and 74 years of age, and a major cause of peripheral neuropathy and peripheralvascular disease.
 
    Clearly, diagnosing and managing the type 2 diabetic represents a tremendous challengeto the primary care provider already besieged with managed care issues, medication costs,liability concerns, and health access.
 
    Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guideto Diagnosis and Management, along with its Continuing Medical Education component,has been designed as a direct result of 5 years of lecturing throughout the country, listening,teaching, and empathizing with fellow primary care practitioners, and our ongoing fightwith this killer disease. I have designed this as an easy-to-reference, state-of-the-art guide toall primary care practitioners, students, caregivers, and patients battling the ravages of thismonster.
 
Ronald A. Codario, MD
Associate Professor of Clinical Medicine
Hospital of the University of Pennsylvania
Thomas Jefferson University Hospital
Philadelphia, PA
RCodario@aol.com
 
REFERENCES
 
1. Budzikowski, A. Obesity, diabetes, and hypertension: a growing epidemic. Cardiol Rev
2003;20:9–10.
 
2. Narayan KM, Boyle JP, Thompson TJ, et al. Lifetime risk for diabetes mellitus in the United
States. JAMA 2003;290:1884–1890.
 
3. Fagan TC, Deedwaqnia PC. The cardiovascular dysmetabolic syndrome. Am J Med
1998;105(Suppl 1A):77S–82S.
 
4. Boden G. Pathogenesis of type 2 diabetes: insulin resistance. Endocrinol Metab Clin North Am
2001;30:801–815.
 
Acknowledgments
 
    To my wife, Celeste who had to put up with me for the 12 months working on this project,and my four children, Ron, Jr., Maria, Christiana, and Joseph for their words of encouragementand inspiration during this ordeal.
 
    A special thank you to Tina Trivelli for transcribing much of this text from my dictation.
 
Contents
 
Dedication 
 
Series Editor’s Introduction 
 
Preface 
 
Acknowledgments
 
Continuing Medical Education
 
Value-Added eBook/PDA
 
1. Pathophysiology of Type 2 Diabetes 
 
2. Guidelines and Classifications 
 
3. Exercise
 
4. Nutrition 
 
5. Obesity and the Metabolic Syndrome 
 
6. Oral Agents for Type 2 Diabetes 
 
7. Insulin Use
 
8. Macrovascular Disease 
 
9. Microvascular Disease
 
10. Diabetic Dyslipidemia 
 
11. Hypertension in Patients With Diabetes
 
12. Glycemic Control
 
13. Risk Reduction in Patients With Diabetes 
 
Resources 
 
Suggested Reading 
 
Index 
 
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