VII Foreword
    Grossman, A.B. (London)
    IX Preface
    Guitelman, M. (Buenos Aires); Bronstein, M.D. (Sao Paulo); Arzt, E. (Buenos Aires)
    1 Implication of Pituitary Tropic Status on Tumor Development
    Donangelo, I.; Melmed, S. (Los Angeles, Calif.)
    9 Anterior Pituitary Cell Renewal during the Estrous Cycle
    Candolfi, M. (Los Angeles, Calif.); Zaldivar, V.; Jaita, G.;
    Seilicovich, A. (Buenos Aires)
    22 Bone Morphogenetic Protein-4 Control of Pituitary Pathophysiology
    Giacomini, D. (Buenos Aires); Páez-Pereda, M.; Theodoropoulou, M. (Munich);
    Gerez, J.; Nagashima, A.C.; Chervin, A.; Berner, S. (Buenos Aires); Labeur, M.
    (Munich); Refojo, D. (Buenos Aires); Renner, U.; Stalla, G.K. (Munich);
    Arzt, E. (Buenos Aires)
    32 Genesis of Prolactinomas: Studies Using Estrogen-Treated Animals
    Sarkar, D.K. (New Brunswick, N.J.)
    50 Dopaminergic D2 Receptor Knockout Mouse: An Animal
    Model of Prolactinoma
    Cristina, C.; García-Tornadú, I.; Díaz-Torga, G.; Rubinstein, M. (Buenos Aires);
    Low, M.J. (Portland, Oreg.); Becú-Villalobos, D. (Buenos Aires)
    64 Vasoinhibins: A Family of N-Terminal Prolactin Fragments that Inhibit
    Angiogenesis and Vascular Function
    Clapp, C.; González, C.; Macotela, Y.; Aranda, J.; Rivera, J.C.;
    García, C.; Guzmán, J.; Zamorano, M.; Vega, C.; Martín, C.;
    Jeziorski, M.C.; de la Escalera, G.M. (Querétaro)
    74 Molecular Mechanisms of Pituitary Differentiation and
    Regulation: Implications for Hormone Deficiencies and
    Hormone Resistance Syndromes
    Drouin, J. (Montréal)
    88 Long-Term Follow-Up of Prolactinomas: Should Dopamine Agonist
    Treatment Be Life-Long?
    Guitelman, M. (Buenos Aires)
    102 Ghrelin: From Somatotrope Secretion to New Perspectives in the
    Regulation of Peripheral Metabolic Functions
    Broglio, F.; Prodam, F.; Riganti, F.; Muccioli, G.; Ghigo, E. (Turin)
    115 Regulating of Growth Hormone Sensitivity by Sex Steroids:
    Implications for Therapy
    Ho, K.K.Y.; Gibney, J.; Johannsson, G.; Wolthers, T. (Sydney)
    129 Acromegaly: Molecular Expression of Somatostatin
    Receptor Subtypes and Treatment Outcome
    Bronstein, M.D. (Sao Paulo)
    135 Gene Therapy in the Neuroendocrine System
    Here?ú, C.B.; Morel, G.R.; Bellini, M.J.; Reggiani, P.C.; Sosa, Y.E.;
    Brown, O.A.; Goya, R.G. (La Plata)
    143 Ectopic ACTH Syndrome
    Isidori, A.M. (Rome); Kaltsas, G.A. (Athens); Grossman, A.B. (London)
    157 Estrogens and Neuroendocrine Hypothalamic-
    Pituitary-Adrenal Axis Function
    De Nicola, A.F.; Saravia, F.E.; Beauquis, J .;
    Pietranera, L. (Buenos Aires); Ferrini, M.G. (Torrance, Calif.)
    169 New Aspects in the Diagnosis and Treatment of
    Cushing Disease
    Labeur, M.; Theodoropoulou, M.; Sievers, C.; Paez-Pereda, M. (Munich);
    Castillo, V.; Arzt, E. (Buenos Aires); Stalla, G.K. (Munich)
    179 Author Index
    180 Subject Index
    The pituitary and its disorders remain of perennial interest, and in a fastdevelopingfield we make no apology for devoting another volume in this seriesto the subject, hard on the heels of Molecular Pathology of the Pituitary [vol.32, 2004] Most intriguingly, this volume also developed from a meeting inSouth America, in this case one based at Iguazu Falls in Argentina, rather thanRio de Janeiro. Once again, a series of national and international experts convergedon one of the most spectacular settings in the world, and I believe wehave included in this volume many of the most scientifically exciting and clinicallyrelevant areas in contemporary neuroendocrinology. But equally, I feel italso reveals much of the enthusiasm and dynamism of neuroendocrinology inSouth America, certainly in two of the largest countries Brazil and Argentina,but increasingly in many of the smaller South American countries. This is anexciting time in neuroendocrinology, and the South American continent is makingsalient and important contributions to its development.
    Such meetings, held in surroundings of outstanding natural beauty, alsoencourage the initiation and deepening of many personal interactions, and Iwould like to underline my own deep thanks to the organizers and all mySouth-American colleagues. My daughter Sophie and I were subject to warmand welcoming local hospitality, and I will always fondly remember this conference.I would also like to take the opportunity to emphasize the totallyunrestricted educational grant from Pfizer in supporting this meeting, demonstratingthat international pharmaceutical companies can play a vital and, whenrequired, disinterested role in the development of clinical science.
    Ashley Grossman, North Devon
    In November 1–4, 2005, in the spectacular setting of Iguazu falls, almost140 professionals in medicine (endocrinologists, neurosurgeons), basic researchand clinical biochemistry were hosted at the scientific meeting ‘PituitaryToday’, where all aspects related to the pituitary gland were discussed.Specialists from Latin America (including delegates from Argentina, Brazil,Mexico, Peru and Venezuela) gathered together for this event, together withexpert speakers from Canada, USA, Germany, England and Australia who attendedthe event as invited guests.
    Different aspects of pituitary physiopathology were covered in severalsymposia. Many of these lectures are now included in this book, including:Tumorigenesis (Melmed, Seilicovich, Arzt), Prolactinomas (Sarkar, Becu-Villalobos, Clapp), Hormone regulation and action (Drouin, Ghigo), GH/acromegaly (Ho, Bronstein, Goya), and HPA axis and Cushing (Grossman, DeNicola, Stalla). In addition, two consensus meetings on the diagnosis and treatmentof pituitary disease (on acromegaly and prolactinomas) were discussedduring the meeting, the one on prolactinomas being reported by Guitelman.
    The meeting took place in a special environment where a scientific, cultural,and social exchange was predominant. In addition, we would like toemphasize that a group of young basic science and clinical fellows were alsoinvited, presenting their results and thereby enriching the debates.
    As coordinators of this event, we would like to express our thanks andrecognition to Pfizer Laboratories who made ‘Pituitary Today’ possible in LatinAmerica; we also would like to mention the excellence of their staff whoseworking capacity allowed this meeting to attain an outstanding internationallevel. We, as volume editors, thank all the contributors to this book of the seriesFrontiers in Hormone Research from Karger Publishers, Basel.
    Mirtha Guitelman, Buenos Aires
    Marcello D. Bronstein, Sao Paulo
    Eduardo Arzt, Buenos Aires

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